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KMID : 0811720110150020095
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Korean Journal of Physiology & Pharmacology
2011 Volume.15 No. 2 p.95 ~ p.100
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Regulation of DREAM Expression by Group I mGluR
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Lee Jin-U
Kim In-Sook
Oh So-Ra
Ko Suk-Jin
Lim Mi-Kyung
Kim Dong-Goo
Kim Chul-Hoon
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Abstract
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DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
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KEYWORD
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Calcium, DREAM, Group I mGluR, mGluR5, mGluR1, Pain
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